(Ser(PO₃H₂)²⁷³)-Nek11 (268-283)

CAS: 2243207-06-7

Ref. 01-4104897

Product Information

• Name: (Ser(PO₃H₂)²⁷³)-Nek11 (268-283)
• Brand: Bachem
• Description: Depletion of NEK11 prevents proteasome-dependent degradation of CDC25A, both in unperturbed and DNA-damaged cells. In addition, NEK11 directly phosphorylates CDC25A, and CHK1 (checkpoint kinase 1) directly activates NEK11 by phosphorylating it on Ser²⁷³. Taken together, NEK11 is an important component of the pathway enforcing the G2/M checkpoint, and genetic mutations in NEK11 may contribute to the development of cancer. These results have been shown by Melixetian and coworkers.

Chemical properties

• Molecular weight: 1848.09
• Formula: C₇₇H₁₃₅N₂₂O₂₆PS
• Purity: 97.5%