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Cheruvara and coworkers conducted a single step selection followed by two rounds of competition selection protein-fragment complementation assay (PCA) in order to derive a-synuclein (a-syn) binders capable of inhibiting aggregation. They isolated a 10-residue peptide antagonist, corresponding to the sequence of a-synuclein binding peptide that potently inhibits a-synuclein aggregation and associated toxicity at 1:1 stoichiometry.
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Technical inquiry about: 01-4107364 α-Synuclein Binding Peptide
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