3-(4-Fluorobenzoyl)propionic acid, 97%

CAS: 366-77-8

Ref. 02-A13755

Product Information

• Name: 3-(4-Fluorobenzoyl)propionic acid, 97%
• Synonyms: 4-(4-fluorophenyl)-4-oxobutanoic acid, 3-(4-Fluorobenzoyl)propanoic acid, 3-(p-Fluorobenzoyl)propionic acid, 4-(4-Fluorophenyl)-4-Oxobutanoic Acid, 4-(4-Fluorophenyl)-4-oxobutyric acid, 4-Fluoro-γ-oxobenzenebutanoic acid, 4-Fluorobenzoylpropionic acid, 4-Oxo-4-(p-fluorophenyl)butyric acid, Ba 2833, Benzenebutanoic acid, 4-fluoro-γ-oxo-, Haloperidol metabolite III, NSC 408180, Propionic acid, 3-(p-fluorobenzoyl)-, β-(4-Fluorobenzoyl)propionic acid, β-(p-Fluorobenzoyl)propionic acid, γ-(4-Fluorophenyl)-γ-oxobutanoic acid
• CAS: 366-77-8

Description

7-Fluoro-1-tetralone was prepared from 3-(4-fluorobenzoyl)-propionic acid by Wolff-Kishner reduction followed by ring closure with polyphosphoric acid and other substituted 1-tetralones where commercially available. Reduction of 3-(4-fluorobenzoyl)propionic acid with an excess of tert-butylamine borane (TBAB) in the presence of AlCl3 provided 4-(4-fluorophenyl)-1-butanol (87) in 63% yield for the synthesis of LM-1507 sodium salt. Penfluridol 1-[4,4-bis(4-fluorophenyl)butyl]-4-(4-chloro-3-trifluoromethylphenyl)- 4-hydroxypiperidine, C 28 H 27 ClF 5 NO, M r 523.99, mp 105 - 107°C, is obtained by reducing the ketone of 3-(4-fluorobenzoyl)propionic acid into a lactone.This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

• Brand: Alfa Aesar By Thermo Fisher Scientific

Chemical properties

• Molecular weight: 196.18
• Formula: C₁₀H₉FO₃
• Purity: 97%
• Color/Form: Crystals or powder or crystalline powder or fused solid, White to cream
• InChI key: WUYWHIAAQYQKPP-UHFFFAOYSA-N