10-[3-(4-Methyl-1-piperazinyl)propyl]-10H-phenothiazine

CAS: 84-97-9

Ref. 3D-AAA08497

Product Information

• Name: 10-[3-(4-Methyl-1-piperazinyl)propyl]-10H-phenothiazine
• Synonyms: 10-(3-Methylpiperazinopropyl)phenothiazine, 10-(γ-Methylpiperazinopropyl)phenothiazine, 10-[3-(1-Methylpiperazin-4-yl)propyl]phenothiazine, 10-[3-(4-Methyl-1-piperazinyl)propyl]phenothiazine, 10-[3-(4-Methylpiperazinyl)propyl]phenothiazine, 10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine, 10H-Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-, NSC 638694, P 725, Peragal, Perazin, Perazine, Pernazine, Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-, Psytomin, Taxilan
• CAS: 84-97-9

Description

10-[3-(4-Methyl-1-piperazinyl)propyl]-10H-phenothiazine is a potent inhibitor of the human p-glycoprotein (Pgp) transporter. It has been shown to inhibit the activity of PGP in vitro and in vivo, as assessed by flow assay, particle size, and titration calorimetry. 10-[3-(4-Methyl-1-piperazinyl)propyl]-10H-phenothiazine also inhibits the activity of the α7 nicotinic acetylcholine receptor. This drug may be useful for treating infectious diseases such as HIV/AIDS, hepatitis C, and malaria. 10-[3-(4-Methyl-1-piperazinyl)propyl]-10H-phenothiazine binds to crystalline cellulose and causes drug interactions with drugs that are substrates for other transporters such as p -glycoprotein.

• Brand: Biosynth

Chemical properties

• Molecular weight: 339.5 g/mol
• Formula: C₂₀H₂₅N₃S
• Purity: Min. 95%