Product Information
- Carbamic acid trichloroethyl ester
- Carbamic acid, 2,2,2-trichloroethyl ester
- Ethanol, 2,2,2-trichloro-, 1-carbamate
- Ethanol, 2,2,2-trichloro-, carbamate
- Trichlorourethan
- Trichlorourethane
- Voluntal
Trichloroethanol is a chemical compound with the molecular formula CHClCHOH. It is an organic solvent that has been used in the manufacture of lacquers and varnishes, as well as in pharmaceuticals to dissolve resins before making tablets. Trichloroethanol also has been used for therapeutic purposes for the treatment of autoimmune diseases, bowel disease, cancer and metabolic disorders. Trichloroethanol is metabolized by cytochrome P450 enzymes to produce its active form trichloroacetic acid. The metabolites may then bind to DNA, inhibiting RNA synthesis and protein synthesis. This process leads to cell death by apoptosis. Trichloroethanol is also metabolized by glycosidic bond hydrolysis that leads to the formation of a bicyclic heterocycle intermediate which reacts with fatty acids to produce acrolein and other reactive aldehydes that are cytotoxic and can cause oxidative stress in cells.
Chemical properties
Technical inquiry about: 3D-AAA10769 2,2,2-Trichloroethyl carbamate
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