21-Deoxydexamethasone
CAS: 426-15-3
Ref. 3D-AAA42615
| 5mg | Discontinued | ||
| 10mg | Discontinued | ||
| 25mg | Discontinued | ||
| 50mg | Discontinued | ||
| 100mg | Discontinued |
Product Information
- (11β,16α)-9-Fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
- 9-Fluoro-11β,17-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione
- Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17-dihydroxy-16α-methyl-
- Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-, (11β,16α)-
21-Deoxydexamethasone is a synthetic corticosteroid that has been extracted from the adrenal cortex of animals. It is hydrolysed to deoxycorticosterone, which is then converted to corticosterone in the liver. The 21-deoxysteroid and its derivatives are used as a source of cortisone, while the 21-hydroxylated compounds are used in some synthetic glucocorticoids. Deoxycorticosterone can also be converted into hydrocortisone by β-glucuronidase. It has been shown that this drug has a high urinary excretion rate (approximately 50%), and has been analysed using spectrometry to identify conjugates. Chemical ionisation was used for identification of metabolites in urine samples, with detection limits of 0.1 ng/mL for metabolites such as 17α-dehydrodeoxycortisol and 17α-hydroxydeoxycortisol
