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Product Information
7-Aminoindolin-2-one is a pro-apoptotic agent that induces cell death by binding to the histone H3. It binds to the hydroxyl group of lysine residues in the amino-terminal tail of H3, which causes conformational changes that stimulate apoptosis. 7-Aminoindolin-2-one also inhibits aurora B kinase and phosphorylation, leading to selective inhibition of hepg2 cells. In vivo efficacy has been demonstrated in mice. 7-Aminoindolin-2-one also induces polyploidy and acylureido formation, which may be responsible for its antiangiogenic properties.
Chemical properties
Technical inquiry about: 3D-ABA36932 7-Aminoindolin-2-one
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