4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile

CAS: 675126-26-8

Ref. 3D-ACB12626

Product Information

• Name: 4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile
• Synonyms: 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile, 2-Nitro-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile, 2-Nitro-4-methoxy-5-[3-(morpholin-4-yl)]propoxybenzonitrile, 4-Methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitrobenzonitrile, Gefitinib Intermediate 1
• CAS: 675126-26-8

Description

4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile is a synthetic intermediate for the synthesis of gefitinib, an anticancer medicine that is used to treat non-small cell lung cancer. The compound reacts with chloro-, 3-chloro-4-fluoroaniline and benzamide in the presence of phosphoric acid to produce the desired product. The reaction proceeds through a transfer hydrogenation mechanism, which is catalyzed by palladium chloride. This process produces 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile at high yield and with excellent purity. It has been shown that the reaction intermediates can be salified with hydrochloric acid or hydrobromic acid to form a stable salt.

• Brand: Biosynth

Chemical properties

• Molecular weight: 321.33 g/mol
• Formula: C₁₅H₁₉N₃O₅
• Purity: Min. 95%