MDM2 Antagonist IV, Nutlin-3a
CAS: 675576-98-4
Ref. 3D-ACB57698
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Estimated delivery in United States, on Friday 28 Jun 2024
Product Information
Name:
MDM2 Antagonist IV, Nutlin-3a
Synonyms:
- (-)-Nutlin 3
- 2-Piperazinone, 4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-
- 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-yl]carbonyl]piperazin-2-one
- Nutlin-3a
- Piperazinone, 4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-
- Sml 0580
CAS:
Description:
Nutlin-3a is a potent and selective inhibitor of the MDM2 protein, which is an important regulator of p53. Nutlin-3a was shown to be less toxic than other chemical inhibitors in a model system. Nutlin-3a has been shown to induce significant cytotoxicity in cancer cells, but not in normal cells. This may be due to its ability to activate the apoptosis pathway by inhibiting the expression of pro-survival proteins such as Bcl-2 and Akt.
Brand:
Biosynth
Long term storage:
Notes:
Chemical properties
Molecular weight:
581.49 g/mol
Formula:
C30H30Cl2N4O4
Purity:
Min. 95%
MDL:
Melting point:
Boiling point:
Flash point:
Density:
Concentration:
EINECS:
Merck:
HS code:
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