Product Information
- Gw 485801
- P,P,P′,P′-Tetraethyl P,P′-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis[phosphonate]
- Phosphonic acid, P,P'-[2-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-, tetraethyl ester
- Phosphonic acid, P,P′-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-, P,P,P′,P′-tetraethyl ester
- Phosphonic acid, [[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-, tetraethyl ester
- Sr 12813
- Tetraethyl [2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethene-1,1-diyl]bis(phosphonate)
SR 12813 is a drug that inhibits the activity of p-glycoprotein (P-gp) and other drug transporters. It has been shown to inhibit the expression of P-gp in hepatocyte-like cells, which makes it a potential therapeutic agent for cancer patients with bowel diseases. SR 12813 also has a high affinity for polymerase chain reaction (PCR) amplification and shows synergistic effects with taxol in mouse monoclonal antibody models. The molecular mechanism of SR 12813 is not yet known, but it may be an ubiquitin ligase or a toll-like receptor inhibitor.
Chemical properties
Technical inquiry about: 3D-BFA41139 SR 12813
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