Product Information
GSK 2837808A is a small molecule that inhibits mitochondrial respiration and ATP synthesis. It binds to the mitochondrial receptor, which is found on the outer membrane of mitochondria. GSK 2837808A has been shown to inhibit tumor growth in deficient mice and human cancer cells, due to its ability to induce apoptosis by activating caspase-1. Inhibition of mitochondrial respiration may also have an effect on cellular energy metabolism, as well as epithelial mesenchymal transition. GSK 2837808A has also been shown to inhibit glutamate dehydrogenase, which can lead to decreased production of neurotransmitters such as dopamine and serotonin. GSK 2837808A also inhibits aerobic glycolysis in cancer cells, leading to a decrease in glucose uptake.
Chemical properties
Technical inquiry about: 3D-BG170579 GSK 2837808A
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