Toxoplasma Gondii IgM Hybrid Human Monoclonal Antibody
Ref. 3D-BM1404
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Product Information
Characterized disease state sera are critical components in the development and manufacture of diagnostic tests. However, sourcing of these sera is complicated, time-consuming, and sometimes suitable material is not available at all. Our Toxoplasma Gondii IgM Hybrid Human Monoclonal Antibody is produced in mice genetically modified to express human IgM heavy chain constant region. They are then concentrated and spiked into an IgG depleted and delipidised human serum matrix which ensures that the final product is as close as possible to the natural disease state IgM positive human plasma. As part of the selection process for each antibody multiple clones were analysed by commercially available IgM assays and the clones with the most reactivity were selected for commercialization. Testing in both ELISA and bead-based applications shows the products behave in an almost identical manner as the natural source.
Toxoplasma Gondii is a microscopic, single-celled parasite that can infect a variety of warm-blooded animals, including humans. This parasite is responsible for the disease called toxoplasmosis. Toxoplasma gondii is a member of the phylum Apicomplexa, which also includes other important parasitic organisms. The life cycle of Toxoplasma gondii involves both sexual and asexual stages. Cats, both domestic and wild, are the definitive hosts where sexual reproduction occurs. The asexual stages can occur in any warm-blooded animal, including humans. The primary modes of transmission to humans include ingestion of oocysts shed in the feces of infected cats, consumption of undercooked or raw meat containing tissue cysts. Transmission can also occur through organ transplantation and blood transfusions. In healthy individuals, toxoplasmosis may cause mild flu-like symptoms or go unnoticed. However, for individuals with weakened immune systems (such as those with HIV/AIDS, organ transplant recipients, or individuals undergoing certain medical treatments), the infection can cause more severe complications. Congenital toxoplasmosis can result in serious birth defects if a pregnant woman becomes infected.
Chemical properties
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