Amiloride hydrochloride

CAS: 2016-88-8

Ref. 3D-CAA01688

Product Information

• Name: Amiloride hydrochloride
• Synonyms: Amiloride Hydrochloride, Amiloride HCl, (3,5-diamino-6-chloropyrazin-2-yl)-N-(diaminomethylidene)oxomethanaminium, 1-(3,5-Diamino-6-chloropyrazinecarboxyl)guanidine hydrochloride, 2-Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, hydrochloride (1:1), 3,5-Diamino-N-(amino iminomethyl)-6-chloropyrazinecarboxamide hydrochloride, Amilorid hydrochloride, Amipramidine, Amipramizide, Amiprazide, Colectril, Guanamprazine hydrochloride, Midamor, MK-870 hydrochloride, N-Amidino-3,5-diamino-6-chloropyrazinamide hydrochloride, N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride, N-amidino-3,5-diamino-6-chloropyrazinecarboxamide monohydrochloride, N-amidino-3,5-diamino-6-chloropyrazinecarboxamide, monochlorhydrate, N-Amidino-3,5-diamino-6-chlorpyrazincarboxamidmonohydrochlorid, N-amidino-3,5-diamino-6-cloropirazinacarboxamida, monoclorhidrato, Nilurid, Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride, Pyrazinecarboxamide, N-amidino-3,5-diamino-6-chloro-, monohydrochloride

Description

Amiloride is a potassium-sparing diuretic drug that inhibits the epithelial sodium channel in the apical membrane of the renal tubular cells. This increases the cytosolic calcium concentration, which leads to increased exchange of sodium and potassium ions in the cell. Amiloride has been used for the treatment of eye disorders and nonsteroidal anti-inflammatory drugs (NSAIDs), but has not been shown to be effective against cancer. Studies have shown that amiloride can inhibit axonal growth and tumor formation in mice. Amiloride hydrochloride has also been used as an analytical reagent for measuring cytosolic Ca2+, with an optimum concentration at 1mM.

• Brand: Biosynth

Chemical properties

• Molecular weight: 266.09 g/mol
• Formula: C₆H₈ClN₇O·HCl
• Purity: Min. 95%