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2-Ethyl-6-nitro-2H,3H-imidazo[2,1-b][1,3]oxazole
CAS: 127692-13-1
Ref. 3D-CFA69213
| 25mg | 358.00 € | ||
| 250mg | 1,429.00 € |
Product Information
2-Ethyl-6-nitro-2H,3H-imidazo[2,1-b][1,3]oxazole is a synthetic drug that has been shown to be effective against tuberculosis. It inhibits bacterial growth by binding to DNA-dependent RNA polymerase and preventing transcription and replication. 2ENI is the first new antibiotic of this class to enter clinical studies. 2ENI has been shown to have bactericidal activity in mammalian cells against various strains of tuberculosis, including multidrug resistant TB (MDRTB), and pretomanid-resistant TB (PRTB). In addition, it also inhibits the biosynthesis of rifampin and other antibiotics that are used for the treatment of tuberculosis. 2ENI has a pharmacokinetic profile similar to rifampin and other drugs in its class; however, it does not inhibit human DNA gyrase or topoisomerase IV. This may explain why 2ENI does not show
Chemical properties
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