Dengue virus type 4 NS1 antigen, recombinant
Ref. 3D-CL6251
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Product Information
Dengue virus is a member of the Flaviviridae family and is responsible for causing dengue fever in humans. It is transmitted to humans primarily via the Aedes aegypti and Aedes albopicto female mosquitoes which acquire the virus while feeding on the blood of an infected person. Although this virus can inflict asymptomatic or mild symptoms in patients, it can lead to severe infectious such as dengue hemorrhagic fever, also known as dengue shock syndrome.
The Dengue Virus non-structural protein 1 (NS1) is an important glycoprotein antigen in Dengue viral replication and is secreted from infected host cells as a hexamer. As a secreted hexamer the NS1 protein contains a detergent-sensitive central cavity, hosting around 70 lipid molecules which may allow the NS1 to interact with cell surface glycosaminoglycans and to attach to the cell membranes of the host cells. Once the NS1 is anchored into the surface membrane of infected host cells it appears as a membrane associated homodimer. It is believed that NS1 may interact with complement proteins leading to protection of the Dengue virus from complement-dependent lysis and furthermore may be involved in systemic immunity and contribute to vascular leakage, coagulopathy and thromobocytopenia.The global prevalence of dengue fever is significant and while there are numerous diagnostic tests on the market at present for dengue virus, there are few flavivirus panel assays and no specific dengue virus therapeutics available. Cymit Quimica’s biologics division is leading the field in the development of these target recombinant proteins and monoclonal antibodies. Our range of Dengue virus proteins and antibodies provides global development teams and researchers with access to vital and new raw material to test samples, in the race to diagnose patients earlier and help with vaccine development. We offer dengue virus proteins including envelope and NS1 from serotypes 1-4 and dengue virus monoclonal antibodies, for research and diagnostic purposes.
Chemical properties
Technical inquiry about: 3D-CL6251 Dengue virus type 4 NS1 antigen, recombinant
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