Product Information
- 5Fpb22
5F-PB-22 is an ester-type synthetic cannabinoid that acts as a full agonist at cannabinoid receptors CB1 and CB2 (EC50 = 2.8 nM and 11 nM, respectively)1. Activation of the receptors results in Gi/o-dependent functional inhibition of adenylate cyclase, leading to reduced intracellular cAMP levels. In vitro, 5F-PB-22 showed toxicity in cardiac and neuronal cell lines2. Studies on mice models show it more effectively triggers a number of biological processes, including activation of G-protein-gated inwardly rectifying K+ channels, when compared to Δ9-THC3. In vivo responses on experimental mice models are in line with other synthetic cannabinoid receptor agonists and show suppression of locomotor activities as well as induction of hypothermia and bradycardia3.
Chemical properties
Technical inquiry about: 3D-CP175132 5F-PB 22
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