Product Information
SB 399885 Hydrochloride is a selective 5-HT2A receptor antagonist, which has been shown to reduce food intake and body weight in animal models. SB 399885 Hydrochloride is also a potent and selective 5-HT6 receptor antagonist, with an IC50 of 0.4 nM. SB 399885 Hydrochloride inhibits the activation of the paraventricular nucleus (PVN) neurons by 5-hydroxytryptamine (5-HT) and attenuates the activation of the nucleus accumbens (NAc) neurons by 5-HT. SB 399885 Hydrochloride also blocks the appetitive responses induced by stimulation of the PVN or NAc by 5-HT.
Chemical properties
Technical inquiry about: 3D-CRA71381 SB 399885 Hydrochloride
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