Product Information
- H-GRGDSPK-OH
- H-Gly-Arg-Gly-Asp-Ser-Pro-Lys-OH
- glycyl-N~5~-(diaminomethylidene)-L-ornithylglycyl-L-alpha-aspartyl-L-seryl-L-prolyl-L-lysine
GRGDSPK is the sequence found in cell binding region of fibronectin and many other proteins. The sequence, referred to as RGD, is critical for facilitating cell adhesion.-RGD peptide is an adhesive peptide which can be used in a biomaterial context to attach cells to a range of materials. RGD has many applications including as an antigen for integrin adhesion of thymocytes to thymic epithelial cells. RGD can be used as a blocking peptide to study bacteria and fibronectin. RGD can also be used on collagen-coated plates for study of integrins' role in progenitor cell differentiation. Delivery of RGD peptide inhibits bone mineralization in a dose-dependent manner so GRGDSPK is used to study the role of integrins in bone formation. The presence of RGD peptide dramatically alters bone morphology, with a disruption of osteoblast and mineralized matrix organisation. RGD is a vital research tool in bone formation and integrin.
Chemical properties
Technical inquiry about: 3D-CRB1000549 RGD Peptide GRGDSPK
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