SRC Substrate Peptide
Ref. 3D-CRB1000603
| 1mg | 202.00 € | ||
| 500µg | 164.00 € |
Product Information
- KVEKIGEGTYGVVYK-acidH-Lys-Val-Glu-Lys-Ile-Gly-Glu-Gly-Thr-Tyr-Gly-Val-Val-Tyr-Lys-OH
Src is a member of the Src family tyrosine kinases (SFKs), a large cytosolic, non-receptor, kinase family that controls multiple signalling pathways in animal cells. SFKs play key roles in cell morphology and differentiation, motility, proliferation and survival. Src contains an N-terminal 14-carbon myristoyl group, a unique segment, an SH3 domain, an SH2 domain, a protein-tyrosine kinase domain and a C-terminal regulatory tail. Src is expressed ubiquitously however it is seen at far higher levels in the brain, osteoclasts, and platelets. Src is a proto-oncogene and elevated levels of Src protein are seen in different tumours including: breast- lung- thyroid- glioblastoma- colorectal- pancreatic- prostate- gastric- biliary tract, ovarian and skin cancer. Src levels are often associated with tumour progression, metastasis and a poor clinical outcome and therefore Src has been investigated as a therapeutic target.
Chemical properties
Technical inquiry about: 3D-CRB1000603 SRC Substrate Peptide
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