Calcitonin, Salmon

Ref. 3D-CRB1001509

Product Information

• Name: Calcitonin, Salmon
• Synonyms: [Cyc(1,7)]H-CSNLSTCVLGKLSQELHKLQTYPRTNTGSGTP-NH2CSNLSTCVLGKLSQELHKLQTYPRTNTGSGTP-amide, Disulfide bridge: Cys1-Cys7H-Cys-Ser-Asn-L eu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Le u-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2 (D
• Brand: Biosynth
• Description: Calcitonin is a peptide hormone excreted by the thyroid parafollicular cells to regulate calcium and phosphorus levels. Calcitonin acts in opposition to parathyroid hormone (PTH) and vitamin D. Calcitonin functions by inhibiting osteoclast activity in the bones preventing calcium release- there is also inhibition of renal tubular cell reabsorption of calcium and phosphate, so they are excreted preventing a rise in levels.Calcitonin is used for as marker for detection and prognosis of nodular thyroid diseases. Medullary thyroid cancer is one example of the malignant parafollicular cells detectable with the assay, as they present with an increased calcitonin level even at an early stage.Since the discovery of calcitonin over 50 years ago the salmon sourced peptide has been used in numerous treatments including bone metastases, Paget disease, hypercalcaemia, and postmenopausal osteoporosis. The salmon calcitonin has been shown to be equivalent to human form but more active and can be synthetically generated.

Chemical properties

• Molecular weight: 3,429.7 g/mol