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Histone H3 (1-20) pT3, K4Me3-GG-[Lys(5-FAM)]
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Histone H3 (1-20) pT3, K4Me3-GG-[Lys(5-FAM)]

Ref. 3D-CRB1101262

100µg
371.00 €
500µg
452.00 €
Estimated delivery in United States, on Friday 13 Dec 2024

Product Information

Name:
Histone H3 (1-20) pT3, K4Me3-GG-[Lys(5-FAM)]
Synonyms:
  • H-AR(pT)(K/Me3)QTARKSTGGKAPRKQLGG(K/5fam)-NH2AR-[pT]-[K(Me3)]-QTARKSTGGKAPRKQL-GG-[K(5-FAM)]-amideH-Ala-Arg-[pThr]-[Lys(Me3)]-Gln- Thr-Ala-Arg-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Ar g-Lys-Gln-Leu-Gly-Gly-[Lys(5-FAM)]-NH2
Description:

Histone 3 (H3) is one of the four core histones (H2A, H2B, H3 and H4) fundamental in compacting eukaryotic DNA into the nucleosome. Similar to the other core histone, H3 has a globular domain and a flexible N-terminal domain, 'histone tail' which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination. The transcriptional activation or silencing of the chromatin is controlled by ATP-dependent chromatin remodelling factors and histone modifying enzymes which target histone proteins. Both processes function to alter the positioning of the nucleosome, allowing the DNA it to be either available or inaccessible to the transcription machinery.The lysine at position 4 of this peptide has been tri-methylated and it is implicated in studies that this modification may remodel the chromatin so that it is more accessible to transcription factors, which may ultimately increase the level of gene expression. Moreover, the threonine at position 3 has been phosphorylated. It is implicated in recent studies that H3T3 phosphorylation regulates chromosome cohesion and is necessary for chromosomes to be able to align on the metaphase plate.The this peptide is labelled with 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag.

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Biosynth
Long term storage:
Notes:

Chemical properties

Molecular weight:
2,904.5 g/mol
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Hazard Info

UN Number:
EQ:
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H Statements:
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Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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