Neurokinin B Heavy
Ref. 3D-CRB1300292
| 25nMol | 270.00 € |
Product Information
- DMHDFFVG-[U-13C6,15N-Leu]-M-amideH-Asp-Met-His-Asp-Phe-Phe-Val-Gly-[U-13C6,15N-Leu]-Met-NH2
Neurokinin B (NKB) is a member of the tachykinin family of peptides that include substance P (SP), neurokinin A (NKA), endokinins and hemokinins. NKB is encoded by-TAC3-in humans and-Tac2-in rodents and along with the neuropeptide kisspeptin plays an essential role as gatekeeper of puberty.NKB plays a stimulatory role in luteinising hormone (LH) release in a number of species, likely mediated via the secretion of gonadotropin-releasing hormone (GnRH) in a kisspeptin-dependent manner (NKB appears to play a critical role in the control of kisspeptin release). NKB may contribute to the regulation of the reproductive function by metabolic cues. NKB binds with highest affinity to the G-protein coupled neurokinin-3 receptor NK3R- also known as tachykinin receptor 3 (TACR3).The leucine residue at position 9 of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (1), giving this peptide a mass increase of 7 compared to the unlabelled peptide.
Chemical properties
Technical inquiry about: 3D-CRB1300292 Neurokinin B Heavy
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