Complement C3 - Ornithine Heavy
Ref. 3D-CRB1300309
| 25nMol | 379.00 € |
Product Information
- SSKITHRIHWESASL-[U-13C6,15N-Leu]-O-acidH-Ser-Ser-Lys-Ile-Thr-His-Arg-Ile-His-Trp-Glu-Ser-Ala-Ser-Leu-[U-13C6,15N-Leu]-Ornithine-OH
Complement C3 is a fundamental factor featured in all three complement system pathways: the classical, lectin and alternative. To activate the complement cascade C3 associates with C3 convertase to produce C3a and C3b. It is also thought that C3 can be cleaved by proteases outside of the complement cascade. C3b can bind to carbohydrate and protein hydroxyl groups through a thioester bond generated by C3 convertase cleavage. This action allows C3b to be used as a 'marker of foreign molecules such as pathogens and ultimately leads to the assembly of the membrane attack complex (MAC) and anaphylatoxin production.Overall the main functions of the complement system are to mark cells for phagocytosis, the recruitment of inflammatory cells and the cell lysis of bacteria cell by the MAC. The anaphylatoxins C3a and C5a recruit neutrophils and causes the inflammatory response while the MAC produces pores in the bacterial membrane thus causing a Ca2+ influx into the cell and bacterial cell death.The complement system as a whole can be associated with the neurological diseases, bacterial meningitis, thrombotic disorders, neurological and autoimmune diseases.Ornithine, a urea cycle intermediate molecule and a substrate of proline, polyamine and citrulline synthesis, has been found to regulate metabolic processes and where dysregulation occurs it may be involved in diseases such as hyperammonemia and cancer.The Leucine residue at position 17 has been isotopically labelled with carbon-13 (6) and nitrogen-15 (1)
Chemical properties
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