Cathepsin D (349-357) Heavy
Ref. 3D-CRB1300611
| 25nMol | 452.00 € |
Product Information
- H-LSPEDYTL^K-OH
Cathepsin D is an aspartic endo-protease that is ubiquitously distributed in lysosomes. The main function of cathepsin D is to degrade proteins and activate precursors of bioactive proteins in pre-lysosomal compartments, including substrates of endocytosis, phagocytosis and autophagy. Consequently, cathespin D deficiency leads to a strong impairment of the lysosomal-autophagy machinery.Mutations in the gene encoding cathespin D, CTSD, are associated with the pathogenesis of several diseases, including breast cancer and Alzheimer disease.
Chemical properties
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