cathepsin D (55-72) Heavy
Ref. 3D-CRB1300697
| 25nMol | 198.00 € |
Product Information
- H-YSQAV^PAVTEGPIPEVLK-OHYSQA-[U-13C5,15N-Val]-PAVTEGPIPEVLK-acidH-Tyr-Ser-Gln-Ala-[U-13C5,15N-Val]-Pro-Ala-Val-Thr-Glu-Gly-Pro-Ile -Pro-Glu-Val-Leu-Lys-OHU biquitin carboxyl-terminal hydrolase isozyme L1
- Neuron cytoplasmic protein 9.5
- PGP 9.5
- Ubiqui
Cathepsin D is an aspartic endo-protease that is ubiquitously distributed in lysosomes. The main function of cathepsin D is to degrade proteins and activate precursors of bioactive proteins in pre-lysosomal compartments, including substrates of endocytosis, phagocytosis and autophagy. Consequently, cathespin D deficiency leads to a strong impairment of the lysosomal-autophagy machinery.Mutations in the gene encoding cathespin D, CTSD, are associated with the pathogenesis of several diseases, including breast cancer and Alzheimer disease.
Chemical properties
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