Ubiquitin K11 Heavy
Ref. 3D-CRB1300808
| 25nMol | 574.00 € |
Product Information
- H-TLTG(K/H-GG)TITLEVEPSDTIENVK^-OHTLTG-[K(GG)]-TITLEVEPSDTIENV-[U-13C6,15N2-Lys]-acidH-Thr-Leu-Thr-Gly-[Lys(Gly-Gly)]-Thr-Ile-Thr- Leu-Glu-Val-Glu-Pro-Ser-Asp-Thr-Ile -Glu-Asn-Val-[U-13C6,15N2-Lys]-OH
This sequence corresponds to the peptide bond between mammalian Lys11- (K11) linked Ub proteins- where (GG) corresponds to the C-terminus of the side chain appended Ub.Chains containing Lys11 (K11) Ub linkages are considered atypical. However they have been implicated in a range of cellular pathways. K11-Linked Ub, assembled via the ubiquitin ligase: anaphase-promoting complex/cyclosome (APC/C), regulate cell cycle progression via targeting proteins to the proteasome. K11 ubiquitin linkages are also involved in maintaining endoplasmic reticulum homeostasis and maintaining cellular protein homeostasis and have been discovered in protein aggregates found in neurodegenerative diseases, such as Alzheimer's disease and Huntington's disease.The C-terminal lysine residue of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (2), giving this peptide a mass increase of 8 compared to the unlabelled peptide.
Chemical properties
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