Ubiquitin K33 Heavy
Ref. 3D-CRB1300814
| 25nMol | 626.00 € |
Product Information
- H-IQD(K/H-GG)EGIPP^DQQR^-OHIQD-[K(GG)]-EGIP-[U-13C5,15N-Pro]-DQQ-[U-13C6,15N4-Arg]-acidH-Ile-Gln-Asp-[Lys-(Gly-Gly)]-Glu-Gly-Ile-P ro-[U-13C5,15N-Pro]-Asp-Gln- Gln-[U-13C6 15N4-Arg]-OH
This sequence corresponds to the peptide bond between mammalian Lys33- (K33) linked Ub proteins- where (GG) corresponds to the C-terminus of the side chain appended Ub.Lys33-linked polyUb chains are assembled by the HECT E3 ligase AREL1. K33-linked polyUb chains have been linked to DNA damage response and in the regulation of innate immunity. Ubiquitination with K33-linked chains also regulates T-cell receptor function and contributes to the stabilization of actin for post-Golgi transport.The proline residues at position 9, and the N-terminal arginine residue of this peptide are isotopically labelled with carbon-13 (11) and nitrogen-15 (5), giving this peptide a mass increase of 16 compared to the unlabelled peptide
Chemical properties
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