LTX-315 Heavy
Ref. 3D-CRB1301585
| 25nMol | 452.00 € |
Product Information
- H-KKWWKKW(Dip)K^-NH2
LTX-315 is a lactoferricin analogue with oncolytic activity. Bovine lactoferricin is a cationic antimicrobial peptide isolated from cow's milk. LTX-315 induces malignant cell death via the disruption of mitochondrial membranes and elicits anti-cancer immune responses. LTX-315 is able to reprogram the tumour microenvironment by decreasing the local levels of myeloid-derived suppressor cells and the immunosuppressive Tregs and by increasing the frequency of polyfunctional T helper type 1 /type 1 cytotoxic T cells with a simultaneous increase in cytotoxic T-lymphocyte antigen-4 (CTLA4) and drop in programmed death-1 (PD-1) expression levels. LTX-315 results in arrest of mitochondrial respiration, disrupting the mitochondrial network and dissipating the mitochondrial inner transmembrane potential, resulting in the release of mitochondrial intermembrane proteins into the cytosol and ultimately cell death. LTX-315 also creates pores and disintegrates the cytoplasmic membranes, thus releasing damage-associated molecular patterns (DAMPs) associated with immunogenic cell death (ICD). The lysine residue at position nine of this peptide has been isotopically labelled with carbon-13 (6) and nitrogen-15 (2), giving this peptide a mass increase of 8 compared to the unlabelled peptide.
Chemical properties
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