Anti-TDP-43 antibody
Ref. 3D-CRB2005321
| 20µg | Discontinued | ||
| 100µg | Discontinued |
Product Information
TAR DNA binding protein 43 (TDP-43) is a highly conserved protein that binds RNA via its two RNA recognition motifs RRM1 and RRM2, thereby regulating RNA processing. Binding regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation, and shortening. TDP-43 aggregates are linked to numerous neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer's disease (AD), and limbic predominant age-related TDP-43 encephalopathy (LATE). This TDP-43 antibody detects the native form of the protein without modifications. We also have an antibody available to the phosphorylated form, serines 409 and 410.
N01 0.2mg/ml, N03 0.3mg/ml. Used for ELISA (1:1000). Reacts with human.
Western blot image provided courtesy of Dr. Benjamin Ryskeldi-Falcon, MRC-LMB: Anti-TDP-43 antibody (crb2005321) Western Blot analysis of recombinant SUMO-tagged full length wt and R293A TDP-43 (0.5µg) without (-) or with (+) in vitro citrullination using peptidyl-arginine deiminase (PAD4) blotted using batch number N01 and N03 (0.2µg/mL). The asterisk indicates truncated TDP-43.
