Anti-GUCY1A1 antibody - 1mg/mL
Ref. 3D-CRB2005739
| 20µg | 136.00 € |
Product Information
Soluble guanylate cyclases (sGCs) are heterodimeric enzymes that convert GTP to 3',5'-cyclic GMP and pyrophosphate. Most complexes consist of an alpha subunit, such as alpha-1 (GUCY1A1), and a beta subunit, typically beta-1 (GUCY1B3). In the presence of magnesium or manganese ions, enzyme activity is stimulated by nitric oxide (NO). sGCs are the principal receptors for nitric oxide (NO), NO-releasing drugs, and NO-sGC-cGMP signalling. Impaired NO availability within the cell is linked to cardiovascular and metabolic disorders due to the role of sGCs in cGMP signalling pathways._x000D_
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sGC plays a role in several cardiovascular pathways. Reduced sGC function contributes to several conditions, including cardiovascular diseases. GUCY1A1 loss of function mutations are associated with atherosclerosis development, increased risk of hypertension and coronary artery disease. An inactivating mutation in GUCY1A1 is linked to premature coronary artery disease. Individuals with homozygous mutations in GUCY1A1develop autosomal-recessive moyamoya and early-onset achalasia.
Chemical properties
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