Anti-GUCY1A2 antibody - 1mg/mL
Ref. 3D-CRB2005742
| 20µg | 136.00 € |
Product Information
Soluble guanylate cyclases (sGCs) are heterodimeric enzymes that convert GTP to 3',5'-cyclic GMP and pyrophosphate. Most complexes consist of an alpha subunit, such as alpha-2 (GUCY1A2), and a beta subunit, typically beta-1 (GUCY1B3). In the presence of magnesium or manganese ions, enzyme activity is stimulated by nitric oxide._x000D_
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sGCs are the principal receptors for nitric oxide (NO) and NO-releasing drugs. sGC plays a role in several cardiovascular pathways. Diminished sGC function contributes to several conditions, including cardiovascular diseases. sGC-induced cGMP increase ultimately affects vascular relaxation, inhibition of platelet aggregation, and altered neurotransmission._x000D_
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sGC GUCY1A2 is upregulated in several cancers and promotes tumorigenesis. GUCY1A2 regulation is particularly dysregulated in cervical, prostate, and gastric cancer. The expression of GUCY1A2 is being proposed as a prognostic indicator for the outcome of gastric cancer and prostate cancer.
Chemical properties
Technical inquiry about: 3D-CRB2005742 Anti-GUCY1A2 antibody - 1mg/mL
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