Aurora™ Fluor 488 Anti-2SC antibody - 0.7mg/mL
Ref. 3D-CRB2105017_3
| 50µg | 822.00 € |
Product Information
- crb2105017/6773
Succination is a stable post-translational modification of cysteine residues, which modifies protein function or turnover in response to a changing intracellular redox environment. Succination occurs when the Krebs cycle intermediate, fumarate, reacts with cysteine yielding S-(2-succino)cysteine (2SC).
A wide range of proteins are subject to succination, including enzymes, adipokines, cytoskeletal proteins and ER chaperones and succination has been shown to have roles in regulatory biology.An increase in succination of adipocyte proteins is seen in diabetes mellitus and results from nutrient excess derived mitochondrial stress. 2SC therefore serves as a biomarker of mitochondrial stress or dysfunction in chronic diseases, such as obesity, diabetes, and cancer.This Antibody is conjugated to a popular bright green flourescent dye: Aurora TM Fluor 488.
Chemical properties
Technical inquiry about: 3D-CRB2105017_3 Aurora™ Fluor 488 Anti-2SC antibody - 0.7mg/mL
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