AF488 Anti-Peroxiredoxin SO2/3 antibody - 0.65mg/mL
Ref. 3D-CRB2115004
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Product Information
- Alexa Fluor ® 488 Anti-Peroxiredoxin SO2
Peroxiredoxins (Prxs) are a recently identified highly abundant and reactive family of antioxidant enzymes that reduce H2O2 via cysteine residue reactivity and make up the major cellular sink for cellular peroxides. Prxs are essential for preventing neurodegenerative disorders, haemolytic anaemia and inflammation from oxidative stress through the elimination of H2O2.
The cysteine residues of Prx1-4 proteins are converted to thioredoxin (Trx) via a sulfenic intermediate and a disulphide bridge. However due to the slow rate of conversion to the disulfide, the sulfenic intermediate is occasionally over-oxidized to cysteine sulfinic acid (Cys-SO2H) or cysteine sulfonic acid (Cys-SO3H), which leads to the inactivation of the peroxidase activity. Prx proteins exhibit circadian cycles in their oxidation status in the absence of transcription and the inactivated form of the enzyme displays circadian accumulation.
Overoxidized Prxs are also seen in excessive oxidative stress conditions such as the balloon-injured rat carotids, human atherosclerotic lesions, Pyrazole-induced liver Injury, and aged rat liver.
This antibody is conjugated to Alexa Flour® 488, a popular bright green flourescent dye with high pH stability.
Chemical properties
Technical inquiry about: 3D-CRB2115004 AF488 Anti-Peroxiredoxin SO2/3 antibody - 0.65mg/mL
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