Anti-sCTLA-4 antibody CRB4B8 - 1mg/mL
Ref. 3D-CRB5005104
| 20µg | 384.00 € | ||
| 100µg | 513.00 € |
Product Information
Cytotoxic T-lymphocyte-associated protein 4 (CTLA4) in an immunoglobulin superfamily receptor important for downregulating immune responses. CTLA4 is expressed in T-cells where it transmits an inhibitory signal to the cells. The secreted soluble form of CTLA-4 (sCTLA-4) lacks the transmembrane domain as well as the membrane proximal cysteine residue required for covalent homodimerization and therefore sCTLA-4 is only present in monomeric form. In human and mouse sCTLA-4 mRNA expression is mainly detected in resting T-cells, at levels similar to transmembrane CTLA-4 (Tm-CTLA-4) mRNA, however following T-cell activation, Tm-CTLA-4 is upregulated and becomes the predominant transcript. Mutations in CTLA4 are associated with multiple autoimmune diseases, including type 1 diabetes (T1D), Graves' disease (GD), rheumatoid arthritis and celiac disease, an increase of sCTLA-4 is also seen in autoimmune diseases.
1mg/ml. For use in WB and ELISA. Reacts with human.
Chemical properties
Technical inquiry about: 3D-CRB5005104 Anti-sCTLA-4 antibody CRB4B8 - 1mg/mL
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