S-(5²-Adenosyl)-L-methionine iodide

CAS: 3493-13-8

Ref. 3D-DAA49313

Product Information

• Name: S-(5²-Adenosyl)-L-methionine iodide
• Synonyms: (3-amino-3-carboxypropyl){[5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}methylsulfonium iodide (non-preferred name), <span class="text-smallcaps">L</span>-Methionine, S-adenosyl-, iodide, Adenosine, 5′-[(3-amino-3-carboxypropyl)methylsulfonio]-5′-deoxy-, iodide, (3S)-, Adenosine, 5′-[(<span class="text-smallcaps">L</span>-3-amino-3-carboxypropyl)methylsulfonio]-5′-deoxy-, iodide, Adenosine, 5′-[[(3S)-3-amino-3-carboxypropyl]methylsulfonio]-5′-deoxy-, iodide, Adenosine, 5′-[[(3S)-3-amino-3-carboxypropyl]methylsulfonio]-5′-deoxy-, iodide (1:1), Methionine, S-adenosyl-, iodide, S-Adenosyl-<span class="text-smallcaps">L</span>-methionine iodide, S-Adenosyl-L-Methionine Iodide Salt, S-Adenosylmethionine iodide

Description

S-(5²-adenosyl)-L-methionine iodide (SAMMI) is a cytosolic metabolite of the amino acid methionine. It has been found to be immunoreactive in human lung tissue, and its presence is correlated with taurocholate concentration. SAMMI inhibits catechol-O-methyltransferase (COMT), which leads to increased levels of noradrenaline and other catecholamines that are involved in the pathogenesis of lung cancer. SAMMI binds to human lung at the site of injury, leading to ligation of DNA and inhibition of protein synthesis. The effect on protein synthesis is mediated by its ability to repress transcriptional activity through inhibition of RNA polymerase II binding to the promoter regions for genes important in cell proliferation.

• Brand: Biosynth

Chemical properties

• Molecular weight: 526.35 g/mol
• Formula: C₁₅H₂₃IN₆O₅S
• Purity: 80%Min
• Color/Form: Powder