Product Information
- 2-Hydroxy-3-naphthalenecarboxamide
- 2-Hydroxy-3-naphthamide
- 2-Hydroxy-3-naphthoamide
- 2-Hydroxy-3-naphthoic acid amide
- 2-Naphthalenecarboxamide, 3-hydroxy-
- 2-Naphthamide, 3-hydroxy-
- 3-Hydroxy-2-naphthalenecarbamide
- 3-Hydroxy-2-naphthalenecarboxamide
- 3-Hydroxy-2-naphthamide
- 3-Hydroxy-2-naphthoamide
- See more synonyms
- 3-Hydroxynaphthalene-2-Carboxamide
- Bon Acid Amide
- NSC 37060
3-Hydroxy-2-naphthamide is an antimycobacterial agent that inhibits the growth of bacteria by binding to the mycolic acid cell wall. It has been shown to have a higher affinity for Mycobacterium tuberculosis than other species of mycobacteria. 3-Hydroxy-2-naphthamide has also been shown to inhibit the production of reactive oxygen species (ROS) in Thp-1 cells and exhibits anti-inflammatory properties. The antimycobacterial activity of 3-hydroxy-2-naphthamide is due to its functional groups, which bind to the chloride ion and form a covalent bond. This reaction takes place in the presence of hydrochloric acid and proceeds with a reaction time of 2 hours at room temperature. The amido group acts as a leaving group during this reaction, forming an intramolecular hydrogen bond with the N atom in the amido group.
Chemical properties
Technical inquiry about: 3D-DAA66551 3-hydroxy-2-naphthamide
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