Product Information
- Acetic acid, 2-[[(2R)-6,7-dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5-yl]oxy]-
- (+)[(6,7-Dichloro-2-cyclopentyl-2-methyl-1-oxo-5-indanyl)oxy]acetic acid
- 2-[[(2R)-6,7-Dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5-yl]oxy]acetic acid
- R(+)-IAA 94
- Acetic acid, [(6,7-dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5-yl)oxy]-, (R)-
R(+)-IAA-94 is a cytosolic Ca2+ channel blocker that inhibits the voltage-dependent Ca2+ channels in cardiac and smooth muscle cells. It has been shown to reduce the number of Ca2+ channels, leading to reduced intracellular Ca2+, which in turn decreases the mitochondrial membrane potential and leads to cell lysis. R(+)-IAA-94 has also been shown to be effective against congestive heart failure, myocardial infarct, and other cardiovascular disorders. The effects of this drug are mediated through inhibition of voltage-dependent Ca2+ channels and have been shown to work in a model system using t84 cells. This drug is an analogue of iaa-94, which blocks chloride channels and activates KCa3.1 channels.
Chemical properties
Technical inquiry about: 3D-ECA19731 R(+)-IAA-94
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