Product Information
- 2-Nitro-nicotinic acid methyl ester
- Methyl 2-nitro-3-pyridinecarboxylate
- 3-Pyridinecarboxylic acid, 2-nitro-, methyl ester
Methyl 2-nitronicotinate is a chemical that can be used to modify histones. It binds to regulatory regions of DNA, including the epigenome, and can cause changes in gene expression. Methyl 2-nitronicotinate is also a clastogenic agent, which means it can cause chromosomal damage and mutations. Binding experiments have shown that this chemical interacts with effector proteins such as actin filaments and histones lysine. This chemical has been shown to methylate lysine residues on histone H3 (H3K27) and n6-methyladenosine residues on messenger RNA (mRNA). The methylation of these residues may lead to epigenetic changes in cell function and gene expression. Methyl 2-nitronicotinate is also capable of demethylating amide bonds in the protein methionine synthase.
Methyl 2-nitronicotinate is considered a cytostatic agent because it can inhibit cell division
Chemical properties
Technical inquiry about: 3D-ECA97379 Methyl 2-nitronicotinate
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