Product Information
- 7-(Hydroxyimino)Cyclopropa[B]Chromen-1A-Carboxylate Ethyl Ester
- 7-Hydroxyiminocyclopropan[B]Chromen-1A-Carboxylic Acid Ethyl Ester
- Benzo[b]cyclopropa[e]pyran-1a(1H)-carboxylic acid, 7,7a-dihydro-7-(hydroxyimino)-, ethyl ester
- Ethyl 7,7a-dihydro-7-(hydroxyimino)benzo[b]cyclopropa[e]pyran-1a(1H)-carboxylate
- ethyl (7E)-7-(hydroxyimino)-7,7a-dihydrocyclopropa[b]chromene-1a(1H)-carboxylate
CPCCOEt is a glutamate receptor antagonist that binds to the metabotropic glutamate receptor subtype 2 (mGluR2) and blocks its activation. CPCCOEt has been shown to inhibit the death of neurons, axonal growth, and neuronal sprouting in vitro. It also prevents the neurotoxicity induced by glutamate or NMDA in cultured cortical neurons and microdialysis probes. CPCCOEt prevents the opening of voltage-dependent calcium channels, which leads to a decrease in cytosolic Ca2+ levels. This inhibition results in an increase in neuronal survival and protection against excitotoxic injury. CPCCOEt has been shown to have a protective effect on brain damage caused by stroke or cerebral ischemia in animal models.
Chemical properties
Technical inquiry about: 3D-EHA06799 CPCCOEt
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