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Amcasertib (BBI503)
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Amcasertib (BBI503)

CAS: 1129403-56-0

Ref. 3D-EVB40356

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Estimated delivery in United States, on Tuesday 25 Jun 2024

Product Information

Name:
Amcasertib (BBI503)
Description:

Amcasertib is a β-catenin inhibitor that inhibits tumor growth and metastasis. It is currently in clinical trials for the treatment of cancer. Amcasertib inhibits the phosphorylation of β-catenin by GSK3β, which leads to its degradation by proteasomes, thereby reducing cellular levels of β-catenin. Amcasertib has also been shown to enhance the cytotoxicity of folfirinox, an anticancer drug. Amcasertib has a hydroxyl group at C-2 and a carbonyl group at C-4, which are necessary for binding to β-catenin. The lack of a disulfide bond makes amcasertib more stable than other potential β-catenin inhibitors.

Brand:
Biosynth
Long term storage:
Notes:

Chemical properties

Molecular weight:
539.69 g/mol
Formula:
C31H33N5O2S
Purity:
Min. 95%
MDL:
Melting point:
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Concentration:
EINECS:
Merck:
HS code:

Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

Technical inquiry about: 3D-EVB40356 Amcasertib (BBI503)

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