3-Aminoquinuclidine dihydrochloride

CAS: 6530-09-2

Ref. 3D-FA03742

Product Information

• Name: 3-Aminoquinuclidine dihydrochloride
• Synonyms: (3R)-3-ammonio-1-azoniabicyclo[2.2.2]octane, (3S)-3-ammonio-1-azoniabicyclo[2.2.2]octane, 1-Azabicyclo[2.2.2]oct-3-ylamine dihydrochloride, 1-Azabicyclo[2.2.2]octan-3-amine, Dihydrochloride, 1-Azabicyclo[2.2.2]octan-3-amine, hydrochloride (1:2), 3-Amino-1-azabicyclo[2.2.2]octane dihydrochloride, 3-Aminoquiuclidine diHCl, 3-Quinuclidinone HCl, NSC 93906, Quinuclidin-3-amine dihydrochloride, Quinuclidine, 3-amino-, dihydrochloride

Description

3-Aminoquinuclidine dihydrochloride (3-AQDH) is a chiral quinuclidine derivative that is an acetylcholine receptor agonist. It has been shown to bind to the α7 nicotinic acetylcholine receptor with high affinity and selectivity. 3-AQDH has also been shown to crosslink the cholinergic receptor, which may lead to increased sensitivity of the receptor. The binding constants between 3-AQDH and the α7 nicotinic acetylcholine receptors are very high and it has been shown to be enantiopure in its synthesis. 3-AQDH also has a hydrophilic interaction chromatography profile, which separates it from other compounds. This agent may have potential use as a drug for treating Alzheimer's disease and Parkinson's disease due to its ability to inhibit acetylcholinesterase activity.

• Brand: Biosynth

Chemical properties

• Molecular weight: 199.12 g/mol
• Purity: Min. 95%
• Color/Form: Powder