5-Amino-1H-imidazole-4-carboxamide

CAS: 360-97-4

Ref. 3D-FA09803

Product Information

• Name: 5-Amino-1H-imidazole-4-carboxamide
• Synonyms: 5-Aminoimidazole-4-carboxamide, 1H-Imidazole-4-carboxamide, 5-amino-, 1H-Imidazole-4-carboxamide, 5-amino- 5-amino-4-imidazolylcarboxamide, 1H-imidazole-5-carboxamide, 4-amino-, 4(5)-Amino-5(4)-Imidazolecarboxamide, 4-(1-Aminovinyl)-1H-imidazol-5-amine, 4-Amino-1H-imidazole-5-carboxamide, 4-Amino-5-Imidazolecarboxamid, 4-Amino-5-carbamoylimidazole, 4-Amino-5-imidazole carboxamide, 4-Amino-5-imidazolecarboxamide, 4-Amino-5-imidazolecarboxamide monohydrate, 4-Amino-5-imodazole, 4-Carbamoyl-5-aminoimidazole, 4-Carboxamido-5-aminoimidazole, 5-Amino-1H-Imidazole-4-Carboxamid, 5-Amino-1H-imidazole-4-carboxylic acid amide, 5-Amino-3H-Imidazole-4-Carboxamide, 5-Amino-4-Imidazolecarboxamide, 5-Amino-4-Imidazolylcarboxamide, 5-Amino-4-carbamoylimidazole, 5-Amino-4-glyoxalinecarboxamide, 5-Amino-Imidazole-4-Carboxamid, 5-Aminoimidazole-4-Carboxamide, 5-amino-Imidazole-4-carboxamide, AICA, 4-Amino-5-carbamoylimidazole, Aic Aminoimidazolecarboxamide, Aica, Ba 2756, Ba2756 Diazol-C, Imidazole-4-carboxamide, 5-amino-, NSC 7784
• CAS: 360-97-4

Description

5-Amino-1H-imidazole-4-carboxamide is a potent inhibitor of inosine monophosphate dehydrogenase (IMPDH). This enzyme converts inosine 5'-monophosphate (IMP) to xanthosine 5'-monophosphate (XMP) and is essential for the synthesis of purines. By inhibiting IMPDH, 5-amino-1H-imidazole-4-carboxamide prevents the formation of XMP, which leads to the depletion of purines, thereby inhibiting DNA synthesis. In addition to its role as an anti-inflammatory agent, this drug has been shown to reduce disease activity in bowel disease patients by reducing nitrate reductase activity. The molecule has also been shown to inhibit protein kinases such as PKC and MAPK/ERK kinases.

• Brand: Biosynth

Chemical properties

• Molecular weight: 126.12 g/mol
• Formula: C₄H₆N₄O
• Purity: Min. 95%
• Color/Form: Powder