Product Information
AV-412 is a potent and selective inhibitor of the epidermal growth factor receptor (EGFR) that blocks protein synthesis in cancer cells. It also has antiproliferative activity in vitro and in vivo, which may be due to inhibition of cell maturation, such as the inhibition of the kinase domain. AV-412 inhibits the proliferation of tumor cells by blocking EGFR activation and inhibiting growth factor signaling pathways. In mice with autoimmune diseases, AV-412 was shown to increase renal blood flow without affecting heart rate or blood pressure. This drug also has potent antitumor activity against many different cancer cell lines, including renal, breast, prostate, colon, lung, and pancreatic cancer cells.
Chemical properties
Technical inquiry about: 3D-FA103556 AV-412
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