(2S)-2-Amino-5-[[(2R)-2-Amino-3-[(E)-1,2-Dichloro-3,3,3-Trifluoroprop-1-Enyl]Sulfanylpropanoyl]-(Carboxymethyl)Amino]-5-Oxopentanoic Acid
CAS: 122652-97-5
Ref. 3D-FA103820
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Product Information
- Dctfpg
- Glycine, N-(S-(1,2-dichloro-3,3,3-trifluoro-1-propenyl)-N-L-gamma-glutamyl-L-cysteinyl)-, (E)-
- S-[(1E)-1,2-dichloro-3,3,3-trifluoroprop-1-en-1-yl]-L-cysteinyl-N-L-gamma-glutamylglycine
2-Amino-5-[(2R)-2-aminopropanoyl]amino-5-oxopentanoic acid is a metabolite of the drug trifluoromethyl sulfanyl proprionate. It inhibits glutathione synthesis, which leads to increased reactive oxygen species and DNA damage. 2-Amino-5-[(2R)-2-aminopropanoyl]amino-5-oxopentanoic acid also has carcinogenic potential and is mutagenic in bacterial strains. This metabolite has been shown to be cytotoxic against human cells, with a particular potency for the cytoplasm.
Chemical properties
Technical inquiry about: 3D-FA103820 (2S)-2-Amino-5-[[(2R)-2-Amino-3-[(E)-1,2-Dichloro-3,3,3-Trifluoroprop-1-Enyl]Sulfanylpropanoyl]-(Carboxymethyl)Amino]-5-Oxopentanoic Acid
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