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4-Amino-1-tert-butyl-3-(1'-naphthyl)pyrazolo[3,4-d]pyrimidine
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4-Amino-1-tert-butyl-3-(1'-naphthyl)pyrazolo[3,4-d]pyrimidine

CAS: 221243-82-9

Ref. 3D-FA10426

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Estimated delivery in United States, on Tuesday 21 Jan 2025

Product Information

Name:
4-Amino-1-tert-butyl-3-(1'-naphthyl)pyrazolo[3,4-d]pyrimidine
Synonyms:
  • 1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
  • 1-Na-Pp 1
  • 1-Na-Pp1
  • 1-Naphthyl PP 1
  • 1-tert-Butyl-3-(1-naphthyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
  • 1-tert-Butyl-3-naphthalen-1-ylpyrazolo[3,4-d]pyrimidin-4-amine
  • 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-
  • PP1 analog
Description:

4-Amino-1-tert-butyl-3-(1'-naphthyl)pyrazolo[3,4-d]pyrimidine is a JAK2 inhibitor that has been shown to have anti-proliferative effects on prostate cancer cells. It is an analog of the natural compound 1,4-diaminobutane. 4-Amino-1-tert-butyl-3-(1'-naphthyl)pyrazolo[3,4-d]pyrimidine binds to the ATP site of protein kinase JAK2 and prevents phosphorylation of tyrosine residue 1085 in the activation loop. This inhibition leads to decreased activity of signal pathways such as the MAPK pathway and reduced expression of mesenchymal markers. The normal production of fatty acids and lysine is also inhibited by this drug. 4ATBP also causes apoptosis by inhibiting receptor activity and increasing

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Biosynth
Long term storage:
Notes:

Chemical properties

Molecular weight:
317.39 g/mol
Formula:
C19H19N5
Purity:
Min. 95%
Color/Form:
White Powder
MDL:
Melting point:
Boiling point:
Flash point:
Density:
Concentration:
EINECS:
Merck:
HS code:

Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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