Omega-Agatoxin IVa trifluoroacetate
CAS: 145017-83-0
Ref. 3D-FA108461
| 10µg | 338.00 € | ||
| 25µg | 443.00 € | ||
| 50µg | 695.00 € |
Product Information
- H-Lys-Lys-Lys-Cys-Ile-Ala-Lys-Asp-Tyr-Gly-Arg-Cys-Lys-Trp-Gly-Gly-Thr-Pro-Cys-Cys-Arg-Gly-Arg-Gly-Cys-Ile-Cys-Ser-Ile-Met-Gly-Thr-As n-Cys-Glu-Cys-Lys-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Gly-Leu-Ala-OH trifluoroacetate
- Glu-Asp-Asn-Cys-Ile-Ala-Glu-Asp-Tyr-Gly-Lys-Cys-Thr-Trp-Gly-Gly-Thr-Lys-Cys-Cys-Arg-Gly-Arg-Pro-Cys-Arg-Cys-Ser-Met-Ile-Gly-Thr-Asn-Cys-Glu-Cys-Thr-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-D-Ser-Phe-Ala
- Omega-Aga-Ivb
- Omega-Aga-Tk
- Omega-Agatoxin Tk (P-Type Blocker)
- Omega-Agatoxin Tk, Agelenopsis Aperta
- Snx 290
- Ω-Aga-Tk
- Ω-Agatoxin Tk
- ω-Aga-IV A
- See more synonyms
- ω-Agatoxin IV A (funnel-web spider venom)
- ω-Agatoxin IVA
Omega-agatoxin IVa trifluoroacetate is a neurotoxin that inhibits voltage-dependent calcium channels. It blocks the opening of these channels, leading to an increase in cytosolic calcium. This toxin has been shown to be effective in treating autoimmune diseases and also has shown antimicrobial effects against bacteria. Omega-agatoxin IVa trifluoroacetate has a pathogenic mechanism that involves the inhibition of neuronal death by glutamate through its ability to block the release of glutamate from the presynaptic neuron. This toxin also binds to cerebellar Purkinje neurons and prevents them from firing, which leads to paralysis. Omega-agatoxin IVa trifluoroacetate is a glycosylated peptide with a disulfide bond that can be isolated using preparative high performance liquid chromatography (HPLC).
Chemical properties
Technical inquiry about: 3D-FA108461 Omega-Agatoxin IVa trifluoroacetate
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