(D-Arg1,D-Trp7·9,Leu11)-Substance P
CAS: 91224-37-2
Ref. 3D-FA108555
| 1mg | 257.00 € | ||
| 2mg | 418.00 € | ||
| 5mg | 743.00 € | ||
| 10mg | 1,159.00 € | ||
| 25mg | 2,519.00 € |
Product Information
- H-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2 H-(dR)PKPQQ(dW)F(dW)LL-NH2
- (D-Arg1,D-Trp79,Leu11)-Substance P
- H-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2
- D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-Nh2 Hydrochloride
Substance P is a neuropeptide that is involved in the transmission of pain signals from the nerves to the brain. It also has been implicated in inflammatory and autoimmune diseases. Substance P is a potent agonist of the neurokinin-1 receptor, which causes an increase in intracellular calcium ion levels, leading to neuronal excitation. The release of substance P from nerve fibers can be blocked by administration of an analog (e.g., N-acetyl-D-Arg1,D-Trp7·9,Leu11)-substance P H-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu -Leu -NH2). This compound blocks the activation of substance P receptors with high affinity and specificity.
Chemical properties
Technical inquiry about: 3D-FA108555 (D-Arg1,D-Trp7·9,Leu11)-Substance P
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