N-(2-Amino-4,6-dichloro-5-pyrimdinyl)formamide

CAS: 171887-03-9

Ref. 3D-FA11724

Product Information

• Name: N-(2-Amino-4,6-dichloro-5-pyrimdinyl)formamide
• Synonyms: 2,5-Diamino-4,6-DichloroformamidoHcl, 2-Amino-4,6-dichloro-5-formamidopyrimidine, 2-Amino-4,6-dichloro-5-pyrimidinyl formamide, Formamide, N-(2-amino-4,6-dichloro-5-pyrimidinyl)-, N-(2-Amino-4,6-Dichloro-5-Pyri, N-(2-Amino-4,6-Dichloropyrimidin-5-Yl) Formamide, N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide
• CAS: 171887-03-9

Description

N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide is a heterocyclic amide that has been used as a precursor to formyl amides. It is synthesized by the chlorination of malonic acid and subsequent reaction with diethyl 2,4,6-trichloropyrimidine. This process can be carried out in two steps using an inorganic base as a catalyst for the second step. The synthesis of N-(2-amino-4,6-dichloro-5-pyrimidinyl)formamide from malonic acid proceeds in three steps:
Step 1: Chlorinating malonic acid with thionyl chloride
Step 2: Reaction with diethyl 2,4,6-trichloropyrimidine
Step 3: Purification
The reaction time for this process is approximately 4 hours. The product is purified by recry

• Brand: Biosynth

Chemical properties

• Molecular weight: 207.02 g/mol
• Formula: C₅H₄Cl₂N₄O
• Purity: Min. 95%
• Color/Form: Off-white solid.
• InChI: InChI=1S/C5H4Cl2N4O/c6-3-2(9-1-12)4(7)11-5(8)10-3/h1H,(H,9,12)(H2,8,10,11)
• InChI key: InChIKey=XYWHZUCZNRMJGO-UHFFFAOYSA-N
• SMILES: Nc1nc(Cl)c(NC=O)c(Cl)n1