6-Amino-1-propylpyrimidine-2,4(1H,3H)-dione

CAS: 53681-47-3

Ref. 3D-FA129975

Product Information

• Name: 6-Amino-1-propylpyrimidine-2,4(1H,3H)-dione
• Synonyms: 2,4(1H,3H)-pyrimidinedione, 6-amino-1-propyl-, 1-Propyl-6-aminouracil, 2,4(1H,3H)-Pyrimidinedione, 6-amino-1-propyl-, 6-Amino-1-propyl-1H-pyrimidine-2,4-dione, 6-Amino-1-propyl-2,4(1H,3H)-pyrimidinedione, 6-amino-1-propylpyrimidine-2,4(1H,3H)-dione

Description

6-Amino-1-propylpyrimidine-2,4(1H,3H)-dione is a competitive inhibitor of cyclic amp phosphodiesterase (cAMP) that is used to study the enzyme's role in the regulation of cellular processes. 6APPD binds to cAMP with high specificity and inhibits its hydrolysis by phosphodiesterases. The binding site of 6APPD is found in the active site of the enzyme, where it forms a hydrogen bond with the phosphate group of cAMP. The inhibition of cAMP leads to an increase in intracellular levels of cyclic GMP and this increased concentration activates protein kinase G, which leads to an inhibition of calcium ion transport into cells. This inhibition causes necrosis or cell death. 6APPD also has a non-competitive inhibitory effect on allyl alcohol amine acetyltransferase (AAAT), which is responsible for the production of prostaglandin E2

• Brand: Biosynth

Chemical properties

• Molecular weight: 169.18 g/mol
• Formula: C₇H₁₁N₃O₂
• Purity: Min. 95%
• InChI: InChI=1S/C7H11N3O2/c1-2-3-10-5(8)4-6(11)9-7(10)12/h4H,2-3,8H2,1H3,(H,9,11,12)
• InChI key: InChIKey=KTWOUYVBZDZRNV-UHFFFAOYSA-N
• SMILES: CCCn1c(N)cc(=O)[nH]c1=O