2-Amino-3-hydroxy-5-chloropyridine

CAS: 40966-87-8

Ref. 3D-FA152976

Product Information

• Name: 2-Amino-3-hydroxy-5-chloropyridine
• Synonyms: 3-Pyridinol, 2-Amino-5-Chloro-

Description

2-Amino-3-hydroxy-5-chloropyridine is an activator of the human plasminogen activator system. It is a competitive inhibitor of plasminogen activator inhibitor 1 (PAI-1) and has been shown to stimulate urokinase activity in vitro. 2-Amino-3-hydroxy-5-chloropyridine binds to the enzyme 4-hydroxyindole O-methyltransferase, which converts 4 hydroxyindole into indole. This conversion leads to a decrease in the production of 3 aminocarboxymuconate semialdehyde, which is an intermediate in the synthesis of serotonin and melatonin. The effect on serotonin levels may be responsible for its antidepressant activity.

• Brand: Biosynth

Chemical properties

• Molecular weight: 144.56 g/mol
• Formula: C₅H₅ClN₂O
• Purity: Min. 95%
• InChI: InChI=1S/C5H5ClN2O/c6-3-1-4(9)5(7)8-2-3/h1-2,9H,(H2,7,8)
• InChI key: InChIKey=BMRXXBXPVJOAMM-UHFFFAOYSA-N
• SMILES: Nc1ncc(Cl)cc1O